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Single Chamber Ventricular Pacing

Author

Assoc Prof Harry Mond

Published

December 2, 2024

Chronologically, single chamber ventricular pacing was the first method of long-term cardiac pacing. During the early 1990’s, with the introduction of atrial pacing and a plethora of dual chamber pacing modes, it became necessary to design a simple method of recognition of the pacing mode programmed. After a number of iterations, a three letter identification code evolved with a fourth letter to identify a rate adaptive function.To summarize the code:

  • The first letter identifies the chamber paced
  • the second letter the chamber sensed
  • the third letter the response to sensing and
  • the fourth letter “(R)” indicates sensor availability and “R “ denotes the rate adaptive function is programmed ON.

Single chamber ventricular pacing can be identified on the ECG by a:

  • Stimulus artefact (unipolar, red vertical arrow)
  • Broad QRS and T wave (red highlight). It is important when describing the QRS-T as a bundle branch block that “configuration” be added as the impulse is not conducted in the traditional sense through the bundle branches.

There are three programmed modes for single chamber ventricular pacing.

VOO AsynchronousV Ventricular pacingO No ventricular sensingO No chamber response

The stimulus artefact (unipolar, red vertical arrow) continues unabated through the tracing. Provided the ventricle is not refractory, there is a paced QRS-T wave (red highlight). However, if a native QRS is present, the stimulus artefact (red stippled vertical arrow) lies within the refractory period of that intrinsic beat; sinus beat with normal conduction (yellow highlight) or ventricular ectopic (blue highlight).VVI Ventricular inhibitedV Ventricular pacingV Ventricular sensingI Pacemaker output inhibited

The stimulus artefact (unipolar, red vertical arrow) indicates ventricular pacing (red highlight). When a native QRS occurs, it is sensed by the pulse generator and the next paced beat is inhibited (red vertical stippled arrow). There is a ventricular ectopic (yellow highlight) and a sinus beat with prolonged conduction (blue highlight). Following the sensing of the sinus beat (blue vertical stippled arrow), the pacemaker timing cycle is reset, and ventricular pacing follows after an appropriate delay.With single chamber ventricular pacing, there is no pacemaker recognition of atrial activity, unless it conducts to the ventricle.

There is AV block and the sinus P waves (red highlight) are dissociated from ventricular pacing (red vertical arrows). A ventricular ectopic (yellow highlight) is sensed.Ventricular fusion results when pacing and native rhythms clash.

This is common with ventricular pacing (red vertical arrow) and underlying atrial fibrillation with AV conduction (Vs) when the ventricular response is near identical to the pacing cycle (red, yellow and blue highlight each 1000 ms). The fusion beat (V fusion, red stippled arrow) is an amalgam of both native and paced QRS-T.A poorly recognised programmable function with ventricular pacing is Hysteresis.

The appearance on the ECG is confusing because the pacing rhythm appears to violate the programmed low rate. Hysteresis allows the sensing window of the pacemaker to be extended to encourage the native rhythm (1500 ms yellow highlight), although the actual pacing rate without sensing is not altered (1200 ms red highlight). The underlying rhythm is atrial fibrillation and not surprisingly there is ventricular fusion (red stippled arrow, V fusion) after 1200 ms (blue highlight). When hysteresis is applied to atrial fibrillation, the resultant pauses may be symptomatic.In the absence of atrial fibrillation, ventricular pacing may result in retrograde conduction (inverted P waves, red highlight), and this may occur even when anterograde conduction is blocked (complete heart block).

Because the atria contract against closed AV valves, the patient may have significant symptoms such as engorged pulsatile neck veins, persistent pulsatile headache or shortness of breath due to retrograde pulmonary venous flow. When symptomatic, this is referred to as Pacemaker Syndrome and can be cured by upgrading to dual chamber pacing.VVT Ventricular triggeredV Ventricular pacingV Ventricular sensingI Pacemaker output triggeredEarly non-programmable unipolar VVI sensing circuits were subject to oversensing and could lead to symptomatic pacing inhibition.

An early non-programmable unipolar VVI pacemaker implanted in the abdomen. Each time the patient sat up from the prone position, marked dizziness and pre-syncope would occur as a result of abdominal skeletal myopotential inhibition. Consequently, most of the early synchronous or demand pacemakers were VVT.

With VVT pacing, the full energy of the pacing impulse is delivered into the intrinsic QRS (blue arrows, yellow highlight). The actual moment sensing occurs can now be determined (green highlight). If there are no intrinsic beats, pacing appears normal (red highlight, red vertical arrow). Fusion beats can still occur (blue highlight) if the paced beat (red vertical arrow) occurs at the same time as the intrinsic beat.Even though the energy delivery into intrinsic beats does not contribute to the QRS, the pacing rate appears to increase and is energy expensive.

VVT pacing with ventricular bigeminy and couplet. Unlike ventricular pacing (red highlight), the sensed ventricular ectopics (yellow highlight) have the stimulus artefact embedded within the QRS. The early fear that inappropriate continual sensing of interference would lead to pacemaker tachycardia was overcome by extending the pacemaker refractory period (no sensing can occur) to limit the upper pacing rate to ~120 bpm. A very premature ectopic as part of a couplet (blue highlight) is not sensed in the conventional way and lacks a stimulus artefact.More recently VVT pacing has been incorporated into biventricular pacing systems for cardiac resynchronization therapy (CRT). The objective, without sound scientific confirmation, is to try and resynchronize ventricular ectopy to improve outcomes. This may lead to confusing ECG appearances suggesting pacemaker malfunction.

12 lead ECG of biventricular pacing (red highlight) with two stimulus artefacts (Vp); red arrow indicating left ventricular pacing and 40 ms later, blue arrow right ventricular pacing. Note the right bundle branch block configuration with ventricular pacing (yellow highlight). There is ventricular bigeminy (Vs) with the two arrows now embedded well within the native QRS, suggesting that meaningful ventricular resynchronization is unlikely.Let us summarize single chamber ventricular pacing modes:

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